RESEARCH GRANT 2022
We are pleased to announce the 2022 round of the Neuroendocrine Cancer UK Research Grant in support of NET research. This is open to basic science, clinical and translational researchers from investigators across all healthcare disciplines in the UK and Ireland. Applications are invited from UKINETS members. Funds supporting the grant have been raised by Neuroendocrine Cancer UK. The aim of this grant is to provide pump-priming funds to support research projects designed to improve outcomes for patients with Neuroendocrine Tumours and is not to be utilised as part of a bigger research programme.
Ambitious proposals that encourage collaborations between centres are encouraged. It is anticipated that these grants will lead to more substantive grant funding and applicants are required to provide a clear development plan as part of the proposal. Proposals are welcome from researchers in all relevant fields of neuroendocrine tumour research, including all GEP tumours, bronchial and rectal NETs, adrenal and medullary thyroid cancers. However, small cell cancer of lung is beyond the remit of this funding stream. The funds are to be used to cover research costs but not travel expenses, salaries or major equipment.
• One grant of £30,000 is available
• Application forms should be completed on the template below and submitted to Louise Gammon at the UKI NETS Office (email@example.com) by 1700 on 3 October 2022.
• Grants will be assessed by a committee comprising members of the UKINETS Research Committee, UKINETS, Neuroendocrine Cancer UK and at least one external referee
• The successful projects will be listed on the UKINETS and Neuroendocrine Cancer UK websites
• A report will be required on the anniversary of the award and presentation of a research update will be requested at the annual UKINETS meeting
NB: you must be a UKINETS member to apply for this grant
Instructions for completion
• The application should be completed using this template and be no more than four sides of A4 (Arial 11pt)
• Background should be no more than 500 words and provide preliminary data and justification for the proposed work
• Proposal should be no more than 750 words and provide details of what work will be undertaken and how the work will be taken forward in the future
• Costing should include a clear justification for use of the funds and describe existing support for the project
Recent Grant Awardees
Dr Melissa Frizziero, (The Cancer Research UK Manchester Institute, University of Manchester and Christie NHS Foundation Trust) for:
Epigenetic-based biomarker discovery for Extra-Pulmonary NeuroEndocrine Carcinoma (EP-NEC)
Feasibility of serial methylation-based circulating tumour DNA (ctDNA) analysis in patients with advanced EP-NEC, and its potential utility for biomarker discovery and personalised medicine.
EP-NEC is a lethal cancer with increasing incidence and a lack of effective treatments. Biomarkers to inform patient management and drug discovery are warranted. We propose that methylation profiling of matched DNA tumour tissue and serial cell-free DNA (cfDNA) from EP- NEC patients can provide a sensitive method for ctDNA detection for patient stratification and monitoring, and can define heterogeneity of EP-NECs to reveal specific clinical vulnerabilities.
Huge congratulations to Dr Marc Ooft, Consultant Histopathologist, King’s College Hospital – the recipient of the 2020 NCUK Research Grant. The grant will fund a study entitled ‘Improving patient stratification through epigenetic and tumour microenvironment analysis of the 100,000 Genomes project Neuroendocrine tumour cohort.’
The 2020 grant was awarded at our 18th National Conference Online, and is supported by NCUK, including a generous donation of £10,000 from Mr P Moxham
Since 2013 there have been 6 research grants awarded through funds raised by Neuroendocrine Cancer UK (formerly NET Patient Foundation) and UKINETs. The objective of these grants is to offer support for NET research groups to obtain pilot data leading to larger comprehensive studies. To date, all recipients have achieved this objective.
For each grant call there has been an enthusiastic response from NET research groups throughout the UK. The quality of the applications to date has been extremely high, and following external peer review, four applications have been funded. The projects funded to date are summarized below and have furthered our knowledge of NET epidemiology, early diagnosis and biology.
The TransNETS committee was replaced by the UKINETs Research Committee in early 2016. This committee will oversee the application process and award of future NET Patient Foundation grants.
Dr Chrissie Thirlwell, Chair, UKINETS Research Committee